Advanced science (Weinheim, Baden-Wurttemberg, Germany)Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaThyroid Hormone Receptors betaHumansGTP PhosphohydrolasesUncoupling Protein 1
Thyroid Hormone Receptor β1 and PGC1α Coordinately Regulate OPA1/MFN2-Mediated Mitochondrial Fusion and UCP1-Mediated Lipid Browning in ccRCC.
Xiangui Meng, Tiexi Yu, Fang Lv, Weiquan Li, Hongmei Yang, Xiaoping Zhang, Wen Xiao
Published: 202610.1002/advs.202508571
Abstract
The abnormal accumulation of lipids is a hallmark of clear cell renal cell carcinoma (ccRCC). Both the thyroid hormone receptor β1 (TRβ) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) are key regulators of mitochondr…
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