Advanced science (Weinheim, Baden-Wurttemberg, Germany)
HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4.
Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo
Published: 202510.1002/advs.202508541
Abstract
N6-methyladenosine (m6A) is a dynamic RNA modification, which is added by the METTL3-METTL14 methyltransferase complex or METTL16. Unexpectedly, the tyrosine metabolism enzyme 4-hydroxyphenylpyruvate dioxygenase (HPD) is discovered as a methyltransfe…
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