Advanced materials (Deerfield Beach, Fla.)
Spatially Ordered Dual-Atom Nanozymes for Mimicking Substrate-Induced Conformational Locking in Natural Enzymes.
Haoran Shen, Haoliang Huang, Bowen Shu, Peixin Zhang, Zhen-Lin Xu, Weipeng Liu, Shizhang Chen, Yingju Liu
Published: 202510.1002/adma.202521184
Abstract
Natural metalloenzymes achieve exceptional catalytic efficiency and specificity through substrate-induced conformational locking (SCL) across bimetallic sites. However, most nanozymes lack such adaptive microenvironments and dynamic regulatory capabi…
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