Advanced materials (Deerfield Beach, Fla.)
Lock-and-Shield Strategy Enables Stable and Stimuli-Responsive Tumor-Targeted Gene Delivery.
Siqin Chen, Chongzhi Wu, Dandan Wang, Jiahao Zhuang, Zhiyao Li, Bowen Li, Weidong Pan, Bin Liu
Published: 202510.1002/adma.202518041
Abstract
A major challenge to effective cancer gene therapy is the absence of delivery systems that both protect nucleic acids in circulation and release them efficiently inside tumor cells. Nucleic acids are rapidly degraded by nucleases, cleared from the bl…
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