Advanced materials (Deerfield Beach, Fla.)
Redirecting Tryptophan Metabolism Through Host-Microbial Crosstalk to Enhance Precise Bioorthogonal Chemoimmunotherapy.
Yue Sun, Congcong Huang, Chenglong Ma, Chuanqi Zhao, Mengmeng Liu, Zitong Zhu, Yanjie Zhang, Jinsong Ren, Xiaogang Qu
Published: 202510.1002/adma.202517934
Abstract
Bioorthogonal chemistry offers a promising approach for advancing chemoimmunotherapy, yet two critical challenges remain: (1) achieving deep tumor penetration of catalysts while ensuring precise tumor-confined prodrug activation, and (2) reversing me…
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