Advanced materials (Deerfield Beach, Fla.)
A New Strategy for Controlled In Situ Release of IL-2 from Tumor Spheroids Using a NIR-II Light-Mediated Optogenetic Manipulation System.
Hongrui Lin, Junjie Cheng, Rui Li, Chuanwei Zhu, Yan Zhao, Zhiwen Yang, Gang Song, Yiming Huang, Fengting Lv, Haotian Bai, Shu Wang
Published: 202510.1002/adma.202516726
Abstract
Interleukin-2 (IL-2) is a clinically significant immunotherapeutic agent; its short half-life and poor targeting specificity in vivo have made controlled in situ release an important area of investigation. However, traditional 2D cell experiments and…
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