Advanced materials (Deerfield Beach, Fla.)GraphiteOsteoarthritisAnimalsFenofibrateRats
Janus Graphene Oxide Nanoplatform with Oppositely Functionalized Adhesion and Lubrication Enables Local Sustained Fenofibrate Release to Synergistically Halt Osteoarthritis.
Xi Chen, Hongfu Cao, Haoyuan Lei, Na Li, Ping Song, Yi Cao, Weilin Tian, Xiaolin Cui, Tun Yuan, Jie Liang, Qiguang Wang, Yujiang Fan, Xingdong Zhang
Published: 202610.1002/adma.202514327
Abstract
Osteoarthritis (OA) progresses via a destructive cycle involving cartilage damage, friction, lubrication loss, and chondrocyte senescence. Current therapies, limited to temporary lubrication or pain relief, fail to halt OA due to their inability to r…
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