Advanced healthcare materials
Linker Manipulation with Beta3-Amino Acids Potentiates the Efficacy and Safety of PSMA Radiopharmaceuticals.
Xin Gao, Jie Ma, Siqi Zhang, Zheng Chen, Jiang Wu, Dong Dai, Hongyi Huang, Qingshuang Lu, Shuo Jiang, Yuan Miao, Xueyao Chen, Feng Wang, Rui Wang, Lu Wang, Kuan Hu
Published: 202610.1002/adhm.202505128
Abstract
[177Lu]Lu-PSMA-617 has achieved remarkable efficacy in the targeted radionuclide therapy (TRT) of metastatic castration-resistant prostate cancer (mCRPC), yet challenges like salivary gland and renal toxicity remain. Linker manipulation is a well-est…
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