Advanced healthcare materials
Human Progenitor T-Cell Differentiation Regulated by the Mechanical Resistance of Thymus-Mimetic Extracellular Matrices.
Nicholas Jeffreys, Kyle T Ruark, Joshua M Price, Ella M Serrano-Wu, Blake Hanan, Andrew S Khalil, Wei-Hung Jung, Nuria Lafuente-Gómez, Christina M Tringides, Ann Gao, Joshua M Brockman, Andrew Lu, Izabela Zmirska, Kyle H Vining, Junzhe Lou
Published: 202610.1002/adhm.202504316
Abstract
T-cell-based immunotherapies have revolutionized cancer treatment, yet their reliance on patient-derived T-cells limits scalability and accessibility. Engineering functional T-cells de novo from human hematopoietic stem cells (HSCs) represents a prom…
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