Advanced healthcare materials
Synergistic Induction of Ferroptosis by GPX4 Inhibitor and GSH-Depleted Nanoparticles Effectively Reverses Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma PDX Model.
Chen-Song Huang, Chunlei Dai, Qi Liu, Si-Yun Chen, Ya-Hao Guo, Jie-Qin Wang, An-Da Zheng, Xi-Tai Huang, Jun Wu, Xiao-Yu Yin
Published: 202510.1002/adhm.202503694
Abstract
Ferroptosis has emerged as a critical mechanism in overcoming drug resistance in various tumors; however, its role in gemcitabine-resistant pancreatic ductal adenocarcinoma (PDAC) has not been thoroughly explored. Additionally, the effectiveness of f…
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