Advanced healthcare materials
A Novel Metal-Phenolic-Protein Hybrid Nanoparticles With Precise Delivery and Enhanced Penetration Effect for tPA Targeted Thrombolysis and Reduced Hemorrhagic Risk.
Xinyi Zhao, Wendie Wang, Jing Shi, Qi Zhou, Zitong Zhao, Chenyang Li, Mingshuai Tang, Jing Wang, Jing Zhao, Hong Zhang, Jing Qin
Published: 202510.1002/adhm.202503684
Abstract
Ischemic stroke (IS) is a leading cause of mortality and disability worldwide, posing a critical public health challenge. Currently, clinical use of tissue plasminogen activator (tPA) for IS thrombolytic treatment remains many problems in outcomes an…
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