Advanced healthcare materials
Structure-Function Correlation of Clinically Inspired Lipid Nanoparticles for Lung and Spleen Targeted mRNA Delivery.
Natalia Martinez, Haitao Yu, Joshua Iscaro, Hao Wang, Brendan P Dyett, Jacinta White, Celesta Fong, Calum J Drummond, Steven Bozinovski, Jiali Zhai
Published: 202510.1002/adhm.202503612
Abstract
Lipid nanoparticles (LNPs) have emerged as a transformative platform for mRNA delivery. However, challenges such as low endosomal escape efficiency remain key barriers in the field. Herein, we systematically investigate the clinically approved COVID-…
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