Advanced healthcare materials
Boosting mRNA Therapeutics: pHLIP Enhances Endosomal Escape and Gene Expression in Lipid Nanoparticle.
Caixia Liu, Kaixiang Zhang, Ruijie Ge, Wenya Wang, Xueting Liu, Xuan Li, Pei Hao, Honglin Li
Published: 202510.1002/adhm.202502567
Abstract
Messenger RNA (mRNA) has emerged as a transformative technology for combating viral pandemics and malignancies, with lipid nanoparticle (LNP)-based mRNA vaccines playing a pivotal role in the COVID-19 pandemic. However, current LNP face challenges su…
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