Annals of clinical and translational neurology
Lessons Learned From a Delayed-Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease.
Tuhin Virmani, Lakshmi Pillai, Reid D Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia-Rill
Published: 202510.1002/acn3.70276
Abstract
OBJECTIVE: Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore…
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