Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress-induced cellular senescence.

Trophoblast syncytialization is essential for placental function, and its dysregulation contributes to hypertensive disorders of pregnancy (HDPs), which compromise maternal and fetal health. Reduced expression of mitochondrial dihydroorotate dehydrog…

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