FEBS open bio
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M Reza Ahmadian, Björn Stork, Doreen M Floss, Roland P Piekorz
Published: 202510.1002/2211-5463.70164
Abstract
The sirtuin SIRT4 has been implicated in the control of autophagy and mitochondrial quality control via mitophagy. However, the role of SIRT4 in regulating autophagy/mitophagy induced by different stressors is unclear. Here, we show that cells expres…
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