Molecular oncology
ATF4-mediated stress response as a therapeutic vulnerability in chordoma.
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C Christianson, Adrienne M Flanagan, Udo Oppermann, Adam P Cribbs
Published: 202510.1002/1878-0261.70176
Abstract
Chordoma, a rare primary bone malignancy, currently lacks effective targeted therapies. Despite surgical resection and adjuvant radiotherapy, prognosis remains poor. Recent preclinical studies have highlighted potential therapeutic targets, including…
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