Molecular oncology
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells.
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E Sigmund, Michael J Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher
Published: 202510.1002/1878-0261.70169
Abstract
The emergence of resistance to mutant BRAF-specific inhibitors (BRAFi) requires novel strategies for melanoma treatment. The progression of these tumors involves metabolic adaptations, which also affect the cellular redox status. Previous studies hav…
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