Molecular oncology
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach-Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial-Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider-Stock
Published: 202510.1002/1878-0261.70150
Abstract
Cancer stem cells (CSCs) drive tumor initiation, metastasis, and therapy resistance. The role of cytoplasmic cyclin-dependent kinase inhibitor 1A (CDKN1A, p21) in CSC biology remains unclear. Since cytoplasmic p21 correlated with advanced stage and m…
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